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Multiple molecular mechanisms can explain this effect

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The inhibitory synaptic activity was recorded using a high chloride intracellular solution containing (in mM): 126 KCl, 4 NaCl, 1 MgSO 4 , 0.02 CaCl 2 , 0.1 BAPTA, 15 glucose, 5 HEPES, 3 ATP, and 0.1 GTP, pH 7.3 with KOH, 290 mosm/L

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introduction In the past couple of years, Ive blogged a few times about proposed mechanisms of action (MoA) of known antiprion compounds